# Forced Degradation Studies on the Piperine-Based Benzene Sulfonylamidine: The Effect of Acid, Base, and Peroxide on Its Stability
> Aswad M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85142541217
Jurnal / Konferensi: Aip Conference Proceedings
Tahun terbit: 2022
DOI: https://doi.org/10.1063/5.0094726
ISSN: 0094243X
Citations: 0

## Authors
- Aswad M.

## Abstract
A research about the effect of acid, base, and peroxide on the stability of piperine-based benzene sulfonylamidine (PBSA) on the forced degradation studies utilizing High-Performance Liquid Chromatography (HPLC) as the detection method has been conducted. Having biological activity as anticancer, PBSA was derived from the modification of piperine by click-type reaction of thioamide and sulfinyl azide. It was treated in several conditions such as 0.1 N HCl, 0.1 NaOH, and 3% peroxide for 7 days with sampling on days 1 and 7 respectively. This method was evaluated on the SHIMADZU® HPLC system integrated with a PDA detector. The analysis was arranged in an isocratic separation mode in column C-18 (COSMOSIL®), 150 mm x 4.6 mm, column particle size: 5 µm. The mobile phase of methanol and water at a ratio result showed that PBSA was stable to acid, base and peroxide.

## Keywords
- Piperine
- Chemistry
- High-performance liquid chromatography
- Chromatography
- Benzene
- Peroxide
- Degradation (telecommunications)
- Base (topology)
- Methanol
- Forced degradation
- Reversed-phase chromatography
- Organic chemistry
- Telecommunications
- Computer science
- Mathematics
- Mathematical analysis

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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