# New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents
> Haedar J.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85141752404
Jurnal / Konferensi: Marine Drugs
Tahun terbit: 2022
DOI: https://doi.org/10.3390/md20110661
ISSN: 16603397
Kuartil SJR: Q1
Citations: 10

## Authors
- Haedar J.R.

## Abstract
We reported three new members of the theonellapeptolide family from theonellapeptolide II series, namely theonellapeptolides IIb (<b>1</b>), IIa (<b>2</b>), IIc (<b>3</b>), and three known members-IId (<b>4</b>), IIe (<b>5</b>), and Id (<b>6</b>)-from Kodingarengan marine sponge <i>Theonella swinhoei</i> collected in Makassar, Indonesia. The structures of tridecadepsipeptides <b>1</b>-<b>3</b>, including the absolute configurations of their amino acids, were determined by the integrated NMR and tandem MS analyses followed by Marfey's analysis. To the best of our knowledge, <b>1</b> and <b>2</b> are the first theonellapeptolide-type compounds to have a valine residue with <sub>D</sub> configuration at residue position 6. The isolated theonellapeptolide-type compounds <b>1</b>-<b>6</b> showed selective cytotoxic activity against human pancreatic MIA PaCa-2 cancer cells in a nutrient-deprived medium. Among them, the most potent preferential cytotoxicity was observed in new theonellapeptolide IIc (<b>3</b>) and known IId (<b>4</b>), IIe (<b>5</b>), and Id (<b>6</b>).

## Keywords
- Sponge
- Valine
- Residue (chemistry)
- Stereochemistry
- Cytotoxicity
- Amino acid
- Biology
- Chemistry
- Biochemistry
- Botany
- In vitro

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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