# Stability of thioamide type of piperine under acidic and basic conditions
> Hikma N.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85120797721
Jurnal / Konferensi: Journal of Experimental Biology and Agricultural Sciences
Tahun terbit: 2021
DOI: https://doi.org/10.18006/2021.9(Spl-2-ICOPMES_2020).S259.S263
ISSN: 23208694
Kuartil SJR: Q4
Citations: 1

## Authors
- Hikma N.

## Abstract
Thioamide type of piperine, “thiopiperine” is a derivate of piperine that having high potency against breast cancer cells. This research was intended to evaluate the stability of thiopiperine under highly acidic and basic conditions for 72 h at 60⁰C. This study was conducted by the SHIMADZU® UFLC system integrated with a PDA detector, while the analysis was performed in an isocratic separation mode using column C-18 (COSMOSIL®), 150 mm x 4.6 mm, column particle size: 5 µm. Chromatography condition was set using a mobile phase consisting of 50% aqueous acetonitrile with a flow rate of 1 mL/min, while the detection wavelength was 340 nm. The result showed that thiopiperine undergoes extensive degradation under acidic and basic environments.

## Keywords
- Piperine
- Thioamide
- Chemistry
- Chromatography
- Acetonitrile
- Potency
- High-performance liquid chromatography
- Aqueous solution
- Stereochemistry
- Organic chemistry
- Biochemistry
- In vitro

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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