# The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis
> Harapan H.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85116888408
Jurnal / Konferensi: Reviews in Medical Virology
Tahun terbit: 2022
DOI: https://doi.org/10.1002/rmv.2304
ISSN: 10529276
Kuartil SJR: Q1
Citations: 27

## Authors
- Harapan H.

## Abstract
The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) -125; 95% CI: -207, -43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.

## Keywords
- Medicine
- Coronavirus disease 2019 (COVID-19)
- Confidence interval
- Odds ratio
- Meta-analysis
- Internal medicine
- Web of science
- 2019-20 coronavirus outbreak
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- MEDLINE
- Disease
- Pathology
- Infectious disease (medical specialty)
- Political science
- Law
- Outbreak

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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