# Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study
> Thereska D.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85102236123
Jurnal / Konferensi: Anaesthesia
Tahun terbit: 2021
DOI: https://doi.org/10.1111/anae.15458
ISSN: 00032409
Kuartil SJR: Q1
Citations: 462

## Authors
- Thereska D.

## Abstract
Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

## Keywords
- Medicine
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Prospective cohort study
- Coronavirus disease 2019 (COVID-19)
- 2019-20 coronavirus outbreak
- Cohort study
- Cohort
- MEDLINE
- Emergency medicine
- Intensive care medicine
- Virology
- Surgery
- Internal medicine
- Outbreak
- Infectious disease (medical specialty)
- Disease
- Political science
- Law

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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