# Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in colorectal adenocarcinoma
> MISKAD U.A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85092685662
Jurnal / Konferensi: Minerva Medica
Tahun terbit: 2020
DOI: https://doi.org/10.23736/S0026-4806.20.06401-0
ISSN: 00264806
Citations: 7

## Authors
- MISKAD U.A.

## Abstract
BACKGROUND: Programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) are considered have a prognostic value in several malignancies. This study investigated the correlation between PD-L1 expression of tumor cells with the degree of stromal TILs in colorectal adenocarcinoma. METHODS: A cross sectional study design performed by taking 52 colorectal adenocarcinoma samples. The specimens were stained by immunohistochemical procedure using PD-L1 rabbit monoclonal antibody and the degrees of TILs were assessed base on hematoxylin and eosin (H&E) staining. RESULTS: From a total of 52 samples, the positive PD-L1 expression of tumor cells were 44 (84.6%) samples with 22 (50.0%), 18 (40.9%) and 4 (9.1%) samples had low-, moderate-, and high-degree TILs, respectively. While the negative PD-L1 expression were eight (15.4%) samples with 1 (12.5%), three (37.5%) and four (50.0%) samples had low-, moderate-, and high-degree TILs, respectively. A value of P=0.017 (P<0.05) was obtained by the Chi-square test. CONCLUSIONS: This study concluded that there was a significant correlation between PD-L1 expression of tumor cells and the degree of TILs in colorectal adenocarcinoma. This result indicated that the degree of TILs had the potential to be used as a predictive factor for PD-L1 expression of tumor cells in colorectal adenocarcinoma.

## Keywords
- Immunohistochemistry
- Adenocarcinoma
- H&E stain
- Tumor-infiltrating lymphocytes
- Medicine
- Stromal cell
- Colorectal adenocarcinoma
- Monoclonal antibody
- Pathology
- Staining
- Colorectal cancer
- Internal medicine
- Oncology
- Cancer research
- Antibody
- Immunology
- Cancer
- Immunotherapy

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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