# The anticancer activity of two glycosides from the leaves of Leea aequata L.
> Rahim A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85088594870
Jurnal / Konferensi: Natural Product Research
Tahun terbit: 2021
DOI: https://doi.org/10.1080/14786419.2020.1798661
ISSN: 14786419
Kuartil SJR: Q2
Citations: 11

## Authors
- Rahim A.

## Abstract
Two compounds (7-<i>O</i>-methylmearnsitrin (7-OM) and roseoside A (RA) were identified and characterized from the leaves of <i>Leea aequata</i> (<i>L</i>. <i>aequata</i>) L. The cytotoxicity of 7-OM and RA on HeLa cells was performed using MTT. The 7-OM and RA showed significant inhibition of HeLa cell proliferation with an IC<sub>50</sub> of 22 and 20 µg/mL, respectively when compared with the standard vincristin sulphate (VS) (IC<sub>50</sub> of 15 µg/mL). Moreover, the 7-OM and RA significantly inhibit other cancer cells (HEK-293, H228, and H3122) when compared with the VS and the cytotoxic activity of the compounds might show through the induction of apoptosis. Strikingly, annexin-V and PI signals could barely be detected in control cells, while strong fluorescence densities were observed in response to treatment indicating that these compounds have capacity to induce HeLa cell apoptosis. Our results suggest that the anticancer activity of 7-OM and RA was due to the induction of apoptosis.

## Keywords
- HeLa
- Apoptosis
- Cytotoxicity
- Annexin
- IC50
- Pi
- MTT assay
- Cytotoxic T cell
- Chemistry
- Glycoside
- Traditional medicine
- Cell growth
- Cell
- Pharmacology
- Molecular biology
- In vitro
- Biology
- Biochemistry
- Stereochemistry
- Medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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