# Investigation of compounds and biological activity of selected Indonesian marine sponges
> Sahidin I.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85085619929
Jurnal / Konferensi: Natural Products Journal
Tahun terbit: 2020
DOI: https://doi.org/10.2174/2210315509666190627105237
ISSN: 22103155
Kuartil SJR: Q3
Citations: 19

## Authors
- Sahidin I.

## Abstract
Background: Marine sponges provided a great source of natural products with promising biological activity. This study was aimed to investigate the chemical constituents of methanol extracts of selected Indonesian marine sponges (Callyspongia sp., Clathria sp., Melophlus sarasinorum, and Xestospongia sp.), collected from the Saponda Islands, Southeast Sulawesi, Indonesia as well as to evaluate their antimicrobial and antioxidant activities. Methods: LCMS/MS analysis used to identify the compounds. Agar well diffusion and DPPH assays were used to evaluate the antimicrobial and antioxidant activities. Results: Chemical screening reported alkaloids, terpenoids, steroids, and saponins from all investigated sponges. The LC-MS/MS analysis identified various compounds which mainly contained steroids. Antimicrobial activity (against Bacillus subtilis, Escherichia coli, Salmonella enterica, and Candida albicans) was only shown by the Xestospongia sp. extract. Meanwhile, extracts of M. sarasinorum, Xestospongia sp., and Callyspongia sp. exhibited potent radical scavenging activity. Conclusion: The study concluded that the selected sponges could provide various groups of compounds. Methanol extracts of these sponges could be used as sources of antimicrobial and antioxidant agents.

## Keywords
- Antimicrobial
- Sponge
- DPPH
- Antioxidant
- Traditional medicine
- Salmonella enterica
- Biology
- Chemistry
- Candida albicans
- Microbiology
- Bacteria
- Biochemistry
- Salmonella
- Botany
- Medicine
- Genetics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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