Increased Endothelin-1 Lung Level in Obesity Mice

Abstract

Obesity is also strongly associated with various respiratory diseases, such as obstructive sleep apnea syndrome (OSAS), obesity hypoventilation syndrome (OHS), chronic obstructive pulmonary disease (COPD), asthma, and aspiration pneumonia. In other hand, Endothelin-1 (ET-1), a peptide chain which is the most potent vasoconstriction in human body, participates in various pathology mechanisms of respiratory disease at a certain level, but relation between them is less known.This study intends to measure the lung ET-1 levels in obese wistar rats. We used 10 male wistar rats (Ratus Norvegicus), three months in aged, divided in two groups, nonobese group and obese group which were fed with high fat and carbohydrate diet for 21 weeks. The rohrer index was evaluated twice a week to control development of obesity. Lung endothelin-1 from the two groups were assessed using Enzyme-Linked Immunosorbent Assay (ELISA). The data were then compared using independent T test. The results exhibit the significant enhancement of the endothelin-1 lung levels in the obese male rats compared with the lean male rats (p = 0.005). As a conclusion, it is clear that the levels of ET-1 lung in obese rats increase significantly. The further study is needed to find out the role of ET-1 in lung diseases-related obesity.

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