# A viral-vectored multi-stage malaria vaccine regimen with protective and transmission-blocking efficacies
> Yusuf Y.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85074424165
Jurnal / Konferensi: Frontiers in Immunology
Tahun terbit: 2019
DOI: https://doi.org/10.3389/fimmu.2019.02412
ISSN: 16643224
Kuartil SJR: Q1
Citations: 33

## Authors
- Yusuf Y.

## Abstract
Malaria parasites undergo several stages in their complex lifecycle. To achieve reductions in both the individual disease burden and malaria transmission within communities, a multi-stage malaria vaccine with high effectiveness and durability is a more efficacious strategy compared with a single-stage vaccine. Here, we generated viral-vectored vaccines based on human adenovirus type 5 (AdHu5) and adeno-associated virus serotype 1 (AAV1) expressing a fusion protein of the pre-erythrocytic stage Plasmodium falciparum circumsporozoite protein (PfCSP) and the transmission-blocking sexual stage P25 protein (Pfs25). A two-dose heterologous AdHu5-prime/AAV1-boost immunization regimen proved to be highly effective for both full protection and transmission-blocking activity against transgenic P. berghei parasites expressing the corresponding P. falciparum antigens in mice. Remarkably, the immunization regimen induced antibody responses to both PfCSP and Pfs25 for over 9 months after the boosting and also maintained high levels of transmission-reducing activity (TRA: > 99%) during that period, as evaluated by a direct feeding assay. If similar efficacies on P falciparum can be shown following vaccination of humans, we propose that this multi-stage malaria vaccine regimen will be a powerful tool for malaria control, providing greater overall protection and cost-effectiveness than single-stage vaccines.

## Keywords
- Circumsporozoite protein
- Malaria
- Virology
- Plasmodium falciparum
- Vaccination
- Malaria vaccine
- Regimen
- Transmission (telecommunications)
- Immunology
- Biology
- Immunization
- Medicine
- Antigen
- Internal medicine
- Engineering
- Electrical engineering

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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