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White blood cell, procalcitonin, C-reactive protein and TNF-α as prognostic factors in pediatric sepsis
Lawang S.A.
Indian Journal of Public Health Research and Development
Abstract
Sepsis is the leading causes of morbidity and mortality in critical patients in many intensive care units. There were numerous parameter and biomarkers available to confirm the presence of sepsis. The aim of this study was to determine which one the parameter or biomarkers (white blood cell, CRP, procalcitonin and TNF-α) has a role as an outcome predictor in pediatric sepsis patient. This prospective cohort study was conducted in Pediatric Intensive Care Unit Wahidin Sudirohusodo hospital from Januari 2016untilMay 2017. A total of 108 sepsis patients were included. Plasma specimens were collected at admission, then the patients were being followed up for survived or non-survived. The diagnosis of sepsis is using the International Pediatric Sepsis Consensus 2005 criteria. Serum CRP, Procalcitonin TNF-α were measured using Enzyme Linked Immunosorbent Assay technique. Initial serumprocalcitonin level and TNF-α in non-survived children with septic were very significantly higher than those in the survived groupswith p=0.000 with OR2, 46 CI(0, 905-6, 697) in procalcitonin and p=0.000 with OR 44, 69 CI(5, 749–347, 36)in TNF-α. The initial serum level of PCT and TNF-α can be used as a predictor outcome of sepsis patient in children