# FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health
> Koletzko B.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85071600746
Jurnal / Konferensi: Annual Review of Nutrition
Tahun terbit: 2019
DOI: https://doi.org/10.1146/annurev-nutr-082018-124250
ISSN: 01999885
Kuartil SJR: Q1
Citations: 122

## Authors
- Koletzko B.

## Abstract
Variants in the <i>FADS</i> gene cluster modify the activity of polyunsaturated fatty acid (PUFA) desaturation and the lipid composition in human blood and tissue. <i>FADS</i> variants have been associated with plasma lipid concentrations, risk of cardiovascular diseases, overweight, eczema, pregnancy outcomes, and cognitive function. Studies on variations in the <i>FADS</i> genecluster provided some of the first examples for marked gene-diet interactions in modulating complex phenotypes, such as eczema, asthma, and cognition. Genotype distribution differs markedly among ethnicities, apparently reflecting an evolutionary advantage of genotypes enabling active long-chain PUFA synthesis when the introduction of agriculture provided diets rich in linoleic acid but with little arachidonic and eicosapentaenoic acids. Discovering differential effects of PUFA supply that depend on variation of <i>FADS</i> genotypes could open new opportunities for developing precision nutrition strategies based either on an individual's genotype or on genotype distributions in specific populations.

## Keywords
- FADS2
- Polyunsaturated fatty acid
- Biology
- Linoleic acid
- Genotype
- Eicosapentaenoic acid
- Arachidonic acid
- Obesity
- Fatty acid
- Endocrinology
- Genetics
- Internal medicine
- Physiology
- Biochemistry
- Docosahexaenoic acid
- Gene
- Medicine
- Enzyme

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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