# The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation
> Hsu L.C.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85059748035
Jurnal / Konferensi: Journal of Biomedical Materials Research Part B Applied Biomaterials
Tahun terbit: 2019
DOI: https://doi.org/10.1002/jbm.b.34118
ISSN: 15524973
Kuartil SJR: Q2
Citations: 70

## Authors
- Hsu L.C.

## Abstract
In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro. Moreover, the in vivo results also indicated that the GBH wound dressing combined with ADSCs and its culture medium could potentially accelerate wound healing in the mouse and porcine models. The ADSCs presented a possibility of recovery from wounds and injuries through skin regeneration. Therefore, both in vitro and in vivo results demonstrated that the ADSCs can potentially be an effective clinical treatment through the GBH wound dressing, which is a promising evidence-based complementary and alternative medicine for skin regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 278-285, 2019.

## Keywords
- Wound healing
- In vivo
- Regeneration (biology)
- Stem cell
- Gelatin
- In vitro
- Biomedical engineering
- Wound dressing
- Adipogenesis
- Adipose tissue
- Materials science
- Medicine
- Biology
- Cell biology
- Surgery
- Biotechnology
- Internal medicine
- Composite material
- Biochemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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