# Baculovirus-induced fast-acting innate immunity kills liver-stage plasmodium
> Bin Emran T.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85054774330
Jurnal / Konferensi: Journal of Immunology
Tahun terbit: 2018
DOI: https://doi.org/10.4049/jimmunol.1800908
ISSN: 00221767
Kuartil SJR: Q1
Citations: 19

## Authors
- Bin Emran T.

## Abstract
Abstract Baculovirus (BV), an enveloped insect virus with a circular dsDNA genome, possesses unique characteristics that induce strong innate immune responses in mammalian cells. In this study, we show that BV administration in BALB/c mice not only provides complete protection against a subsequent Plasmodium berghei sporozoite infection for up to 7 d after the injection but also eliminates existing liver-stage parasites completely. The elimination of sporozoites by BV was superior to that by primaquine, and this effect occurred in a TLR9-independent manner. At 6 h after BV administration, IFN-α and IFN-γ were robustly produced in the serum, and RNA transcripts of IFN-stimulated genes were markedly upregulated in the liver compared with control mice. The in vivo passive transfer of serum after BV administration effectively eliminated liver-stage parasites, and IFN-α neutralization abolished this effect, indicating that the BV liver-stage parasite-killing mechanism is downstream of the type I IFN signaling pathway. These findings provide evidence that BV-induced, fast-acting innate immunity completely kills liver-stage parasites and, thus, may lead to new malaria drug and vaccine strategies.

## Keywords
- Innate immune system
- Immunity
- Biology
- Plasmodium (life cycle)
- Virology
- Immunology
- Parasite hosting
- Immune system
- Computer science
- World Wide Web

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.