# Genetic diversity of merozoite surface protein-2 in Plasmodium falciparum isolates from Aceh province, Indonesia
> Jamil K.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85045685469
Jurnal / Konferensi: Iop Conference Series Earth and Environmental Science
Tahun terbit: 2018
DOI: https://doi.org/10.1088/1755-1315/125/1/012036
ISSN: 17551307
Citations: 3

## Authors
- Jamil K.

## Abstract
Estimated 3.3 million Indonesian population were infected with malaria. However, extensive genetic polymorphism of the field isolates MSP-2 of P. falciparum represents a major obstacle for the development of malaria treatment. The aim of this study to investigate the genetic diversity of MSP-2 genotype in field isolates of P. falciparum collected in Aceh Province. A total of 90 patients enrolled in this study who were selected from positive malaria from eleven district Hospitals in Aceh from 2013-2015. Data was collected by anamnesis, complete physical examination and laboratory tests for MSP-2. All protocol to diagnose malaria assigned following the WHO 2010 guideline. All samples were stored in Eijkman Biology Molecular Institute, Jakarta.Among 90 samples were 57.7% male and 42.3% female with the most cases ages between 21-30 years old. Allele typing analysis displayed the polymorphic nature of P. falciparum. The MSP-2 have two alleles, 62.2% (56/90) for FC27 type and 58.9% (53/90) for 3D7 type and 21.2% (19/90) for mixed FC27 and 3D7 infection were identified. Diverse allele types from Aceh Province was identified in MSP-2 P. falciparum patients; there is the almost similar number of patients infected with both allele. A moderate level of the mixed allele was also observed.

## Keywords
- Genotype
- Malaria
- Allele
- Biology
- Plasmodium falciparum
- Genetic diversity
- Merozoite surface protein
- Population
- Genotyping
- Veterinary medicine
- Anamnesis
- Medicine
- Internal medicine
- Immunology
- Genetics
- Environmental health
- Gene
- Malaria vaccine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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