# The genetic polymorphism of merozoite surface protein-1 in Plasmodium falciparum isolates from Aceh province, Indonesia
> Jamil K.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85045641436
Jurnal / Konferensi: Iop Conference Series Earth and Environmental Science
Tahun terbit: 2018
DOI: https://doi.org/10.1088/1755-1315/125/1/012037
ISSN: 17551307
Citations: 1

## Authors
- Jamil K.

## Abstract
An estimated of 3.3 million Indonesian population were infected with malaria. However, extensive genetic polymorphism of the field isolates msp-1 of P. falciparum represents a major obstacle for the development of malaria treatment. The aim of this study was to investigate the genetic diversity of msp-1 genotype in field isolates of P. falciparum collected in Aceh Province. A total of 90 patients with malaria (+) were selected from eleven district hospitals in Aceh from 2013-2015. Data were collected by anamnesis, complete physical examination and laboratory tests for msp-1. All protocols to diagnose malaria followed the WHO 2010 guideline. All samples were stored in Eijkman Biology Molecular Institute, Jakarta. Among 90 samples, 57.7% were male, and 42.3% were female with the most cases found between 21-30 years old. From the allele typing analysis of P. falciparum from Aceh; K1, MAD20, and RO33 allele types were identified. MAD20 type was the highest allele found in this study (57.9%). It was found in single and mixed infection. A moderate level of the mixed allele was also observed.

## Keywords
- Plasmodium falciparum
- Genotype
- Biology
- Malaria
- Allele
- Genetic diversity
- Typing
- Indonesian
- Genotyping
- Population
- Anamnesis
- Veterinary medicine
- Genetics
- Medicine
- Immunology
- Internal medicine
- Gene
- Environmental health
- Linguistics
- Philosophy

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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