# Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model
> Yoshida K.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85042766906
Jurnal / Konferensi: Scientific Reports
Tahun terbit: 2018
DOI: https://doi.org/10.1038/s41598-018-21369-y
ISSN: 20452322
Kuartil SJR: Q1
Citations: 20

## Authors
- Yoshida K.

## Abstract
With the increasing prevalence of artemisinin-resistant malaria parasites, a highly efficacious and durable vaccine for malaria is urgently required. We have developed an experimental virus-vectored vaccine platform based on an envelope-modified baculovirus dual-expression system (emBDES). Here, we show a conceptually new vaccine platform based on an adenovirus-prime/emBDES-boost heterologous immunization regimen expressing the Plasmodium falciparum circumsporozoite protein (PfCSP). A human adenovirus 5-prime/emBDES-boost heterologous immunization regimen consistently achieved higher sterile protection against transgenic P. berghei sporozoites expressing PfCSP after a mosquito-bite challenge than reverse-ordered or homologous immunization. This high protective efficacy was also achieved with a chimpanzee adenovirus 63-prime/emBDES-boost heterologous immunization regimen against an intravenous sporozoite challenge. Thus, we show that the adenovirus-prime/emBDES-boost heterologous immunization regimen confers sterile protection against sporozoite challenge by two individual routes, providing a promising new malaria vaccine platform for future clinical use.

## Keywords
- Circumsporozoite protein
- Heterologous
- Virology
- Malaria
- Immunization
- Biology
- Malaria vaccine
- Vaccination
- Plasmodium falciparum
- Immunology
- Antigen
- Biochemistry
- Gene

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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