Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

Abstract

RIT of P. yoelii infected mice led to rapid development of resistance to atovaquone and pyrimethamine. The dose dependent selection of resistance mutants to atovaquone observed during RIT might reflect the outcome of two different causes of malaria treatment failure in human, repeated incomplete treatment with therapeutic dose and repeated inadequate treatment associated with sub-therapeutic dose, and need to be systematically investigated.

Access to Document

Other files and links

• Link to publication in Scopus
• Open Access Version Available

Fingerprint