Evaluation of Salmonella typhi dipstick for detection of IgM antibodies from suspect Typhoid fever patient

Abstract

Salmonella typhi Dipstick have been developedfor detection of IgM antibodies specific against S. typhi on human. In this study, we examined 195 sera from suspect typhoid fever patients with the mean of fever 10. I + 0.5 days by the Dipstick method and compared with blood culture. From 195 suspected typhoid fevea we found positive to Dipstick and cuLture were 72 samples (36.9Vo) and 29 samples (l4.9Vo),respectively.Oncaseswithfeverlessthanl0days,fromll3samples,thepositiverateforDipstickandculturewere5l samples (45.17o) and 21 (18.6Vo), respectively. From data shown above, the Dipstickmethod is more sensitive in detecting IgM antibodies than bLood culture detection o/S. typhi in day I0 afterfever AIso, the positivity rate of Dipstickwas significantly higher than the positivity rate of blood culture ffischer exact test, p<0.01). In conclusion, S. typhi Dipstick may be usefuI for detection lgM antibodies from sus- pected typhoidfever patients and may benefit as epidemiological toolfor S. fyphi infection. More study is stilL in progress to compare the Dipstick method nd PCR from blood and to explore the specificity of this method.

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