# High prevalence of atypical hyperplasia in the endometrium of patients with epithelial ovarian cancer
> Mingels M.J.J.M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_84907242309
Jurnal / Konferensi: American Journal of Clinical Pathology
Tahun terbit: 2014
DOI: https://doi.org/10.1309/AJCPTGJOPXUW6RVO
ISSN: 00029173
Kuartil SJR: Q2
Citations: 11

## Authors
- Mingels M.J.J.M.

## Abstract
OBJECTIVES: The aim of the present study is to determine the prevalence of endometrial premalignancies in women diagnosed with epithelial ovarian cancer (EOC). METHODS: Endometrial and ovarian specimens of 186 patients with EOC were retrospectively selected using the nationwide pathology network and registry, and sections were comprehensively reviewed: 136 (73%) serous, 19 (10%) endometrioid, 15 (8%) mucinous, seven (4%) clear cell, and nine (5%) undifferentiated. Immunohistochemical phenotypes were compared for patients with serous EOC with concurrent endometrial pathology. RESULTS: In 31%, endometrial (pre)malignancy was found: carcinoma in 3%, endometrial intraepithelial carcinoma (EIC) in 4%, and atypical hyperplasia in 24%. Atypical hyperplasia was found in 47% of endometrioid EOCs but in 7% to 33% of other subtypes. Body mass index was higher concurrent to atypical hyperplasia (P=.001). Serous EOC and EIC immunophenotypes were comparable, whereas atypical hyperplasia was expressed differently. CONCLUSIONS: Apart from synchronous endometrial carcinoma, endometrial premalignancies should be taken into account when determining optimal treatment for women diagnosed with EOC.

## Keywords
- Serous fluid
- Medicine
- Atypical hyperplasia
- Endometrial hyperplasia
- Endometrial cancer
- Hyperplasia
- Serous carcinoma
- Clear cell
- Carcinoma
- Endometrium
- Pathology
- Malignancy
- Clear cell carcinoma
- Gynecology
- Cancer
- Oncology
- Ovarian cancer
- Internal medicine

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.