# Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis
> Habibie

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_84902581796
Jurnal / Konferensi: International Journal of Oncology
Tahun terbit: 2014
DOI: https://doi.org/10.3892/ijo.2014.2480
ISSN: 10196439
Kuartil SJR: Q2
Citations: 40

## Authors
- Habibie

## Abstract
Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell lines, we show that survivin is essential for melanoma survival in vitro and in vivo and is targeted by resveratrol. Furthermore, we identify the down regulation of survivin transcription by resveratrol through the suppression of β-catenin and STAT3. In addition, over expression of survivin protects melanoma cells from resveratrol-induced apoptosis. Collectively, these studies establish that targeting survivin could provide an opportunity to treat melanoma patients.

## Keywords
- Survivin
- Resveratrol
- Apoptosis
- Cell cycle
- Cancer research
- Oncogene
- Catenin
- Biology
- Molecular medicine
- Melanoma
- STAT3
- Signal transduction
- Cell biology
- Pharmacology
- Genetics
- Wnt signaling pathway

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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