# Biodegradable polymer scaffold, semi-solid solder, and single-spot lasing for increasing solder-tissue bonding in suture-free laser-assisted vascular repair
> Pabittei D.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_84868214835
Jurnal / Konferensi: Journal of Tissue Engineering and Regenerative Medicine
Tahun terbit: 2012
DOI: https://doi.org/10.1002/term.486
ISSN: 19326254
Kuartil SJR: Q2
Citations: 4

## Authors
- Pabittei D.R.

## Abstract
We recently showed the fortifying effect of poly-caprolactone (PCL) scaffold in liquid solder-mediated laser-assisted vascular repair (ssLAVR) of porcine carotid arteries, yielding a mean ± SD leaking point pressure of 488 ± 111 mmHg. Despite supraphysiological pressures, the frequency of adhesive failures was indicative of weak bonding at the solder-tissue interface. As a result, this study aimed to improve adhesive bonding by using a semi-solid solder and single-spot vs. scanning irradiation. In the first experiment, in vitro ssLAVR (n=30) was performed on porcine abdominal aorta strips using a PCL scaffold with a liquid or semi-solid solder and a 670-nm diode laser for dual-pass scanning. In the second experiment, the scanning method was compared to single-spot lasing. The third experiment investigated the stability of the welds following hydration under quasi-physiological conditions. The welding strength was defined by acute breaking strength (BS). Solder-tissue bonding was examined by scanning electron microscopy and histological analysis was performed for thermal damage analysis. Altering solder viscosity from liquid to semi-solid solder increased the BS from 78 ± 22 N/cm(2) to 131 ± 38 N/cm(2) . Compared to scanning ssLAVR, single-spot lasing improved adhesive bonding to a BS of 257 ± 62 N/cm(2) and showed fewer structural defects at the solder-tissue interface but more pronounced thermal damage. The improvement in adhesive bonding was associated with constantly stronger welds during two weeks of hydration. Semi-solid solder and single-spot lasing increased welding strength by reducing solder leakage and improving adhesive bonding, respectively. The improvement in adhesive bonding was associated with enhanced weld stability during hydration.

## Keywords
- Soldering
- Materials science
- Laser
- Fibrous joint
- Scaffold
- Lasing threshold
- Biomedical engineering
- Optoelectronics
- Composite material
- Optics
- Surgery
- Engineering
- Medicine
- Wavelength
- Physics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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