# Emergence of fluoroquinolone-resistant Streptococcus pyogenes in Japan by a point mutation leading to a new amino acid substitution
> Arai K.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_79951547913
Jurnal / Konferensi: Journal of Antimicrobial Chemotherapy
Tahun terbit: 2011
DOI: https://doi.org/10.1093/jac/dkq477
ISSN: 03057453
Kuartil SJR: Q1
Citations: 19

## Authors
- Arai K.

## Abstract
Amino acid substitutions in fluoroquinolone-resistant S. pyogenes have already been reported from Europe and the USA, including Ser-81→Phe or Tyr and Met-99→Leu in GyrA, as well as Ser-79→Phe, Tyr or Ala and others in ParC. Numerous point mutations were found in parC and parE of S. pyogenes TU-296. In addition, a new amino acid substitution was detected (Glu-85→Ala in GyrA). To our knowledge, there have been no previous reports of this substitution in a clinical isolate of S. pyogenes.

## Keywords
- Streptococcus pyogenes
- Point mutation
- Cytosine
- Levofloxacin
- Microbiology
- Genotype
- Biology
- Quinolone
- Mutation
- Gene
- Genetics
- Antibiotics
- Staphylococcus aureus
- Bacteria

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.