# Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia
> Utama A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_69449103212
Jurnal / Konferensi: World Journal of Gastroenterology
Tahun terbit: 2009
DOI: https://doi.org/10.3748/wjg.15.4028
ISSN: 10079327
Kuartil SJR: Q1
Citations: 35

## Authors
- Utama A.

## Abstract
AIM: To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia. METHODS: Patients with chronic hepatitis (CH, n = 61), liver cirrhosis (LC, n = 62), and hepatocellular carcinoma (HCC, n = 48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing. RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis. CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease.

## Keywords
- Hepatocellular carcinoma
- Hepatitis B virus
- Genotype
- Cirrhosis
- Virology
- Liver disease
- Hepatitis B
- Liver cancer
- Entecavir
- Mutation
- Biology
- Basal (medicine)
- HBx
- Promoter
- Medicine
- Gene
- Virus
- Gastroenterology
- Internal medicine
- Lamivudine
- Genetics
- Gene expression
- Insulin

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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