# ADAMTS13 deficiency with elevated levels of ultra-large and active von willebrand factor in P. falciparum and P. vivax malaria
> De Mast Q.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_62949125310
Jurnal / Konferensi: American Journal of Tropical Medicine and Hygiene
Tahun terbit: 2009
DOI: https://doi.org/10.4269/ajtmh.2009.80.492
ISSN: 00029637
Kuartil SJR: Q2
Citations: 80

## Authors
- De Mast Q.

## Abstract
A deficiency in ADAMTS13 (a von Willebrand factor [VWF] cleaving protease) is associated with accumulation of prothrombogenic unusually large VWF multimers (UL-VWF) in plasma. We studied VWF release and proteolysis in patients with symptomatic Plasmodium falciparum or P. vivax malaria on the Indonesian island Sumba. Malaria patients had significantly lower platelet counts and higher VWF concentrations and VWF activation factors than healthy hospital staff controls. The latter indicates that a higher amount of circulating VWF was in a conformation enabling spontaneous platelet binding. In addition, ADAMTS13 activity and antigen levels were reduced in both malaria groups, and this was associated with the appearance of UL-VWF. The mechanism behind this reduction and the role in malaria pathogenesis needs to be further elucidated. In malaria, endothelial cell activation with increased circulating amounts of active and ultra-large VWF, together with reduced VWF inactivation by ADAMTS13, may result in intravascular platelet aggregation, thrombocytopenia, and microvascular disease.

## Keywords
- ADAMTS13
- Von Willebrand factor
- Malaria
- Plasmodium falciparum
- Plasmodium vivax
- Platelet
- Pathogenesis
- Immunology
- Medicine
- Internal medicine
- Thrombotic thrombocytopenic purpura

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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