# Serum levels of interferon-γ, tumour necrosis factor-α, soluble interleukin-6R and soluble cell activation markers for monitoring response to treatment of leprosy reactions
> Iyer A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_35348947980
Jurnal / Konferensi: Clinical and Experimental Immunology
Tahun terbit: 2007
DOI: https://doi.org/10.1111/j.1365-2249.2007.03485.x
ISSN: 00099104
Kuartil SJR: Q1
Citations: 51

## Authors
- Iyer A.

## Abstract
Identifying pathogen and host-related laboratory parameters are essential for the early diagnosis of leprosy reactions. The present study aimed to clarify the validity of measuring the profiles of serum cytokines [interleukin (IL)-4, IL-6, IL-10, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha], the soluble IL-6 receptor (sIL-6R), soluble T cell (sCD27) and macrophage (neopterin) activation markers and Mycobacterium leprae-specific anti-PGL-I IgM antibodies in relation to the leprosy spectrum and reactions. Serum samples from 131 Indonesian leprosy patients (82 non-reactional leprosy patients and 49 reactional) and 112 healthy controls (HC) from the same endemic region were investigated. Forty-four (89.8%) of the reactional patients had erythema nodosum leprosum (ENL) while only five (10.2%) had reversal reaction (RR). Follow-up serum samples after corticosteroid treatment were also obtained from 17 of the patients with ENL and one with RR. A wide variability in cytokine levels was observed in the patient groups. However, IFN-gamma and sIL-6R were elevated significantly in ENL compared to non-ENL patients. Levels of IFN-gamma, TNF-alpha and sIL-6R declined significantly upon corticosteroid treatment of ENL. Thus, although the present study suggests limited applicability of serial measurement of IFN-gamma, TNF-alpha and sIL-6R in monitoring treatment efficacy of ENL, reactions it recommends a search for a wider panel of more disease-specific markers in future studies.

## Keywords
- Mycobacterium leprae
- Leprosy
- Immunology
- Tumor necrosis factor alpha
- Cytokine
- Medicine
- Interferon
- Antibody
- Interleukin

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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