# Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship
> Kalauni S.K.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_33646461692
Jurnal / Konferensi: Biological and Pharmaceutical Bulletin
Tahun terbit: 2006
DOI: https://doi.org/10.1248/bpb.29.1050
ISSN: 09186158
Kuartil SJR: Q2
Citations: 94

## Authors
- Kalauni S.K.

## Abstract
Malaria is one of the most life-threatening infectious diseases worldwide and claims millions of people's lives each year. The appearance of drug-resistance Plasmodium falciparum has made the treatment of malaria increasingly problematic, and thus, it is a dire need to search the new alternatives of current drugs. In the present study, 44 cassane- and norcassane-type diterpenes isolated from Caesalpinia crista of Myanmar and Indonesia were evaluated for their antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro. Most of the tested diterpenes displayed antimalarial activity, and norcaesalpinin E (28) showed the most potent activity with an IC50 value of 0.090 microM, more potent than the clinically used drug chloroquine (IC50, 0.29 microM). Based on the observed results, a structure-activity relationship has been established.

## Keywords
- Caesalpinia
- Crista
- Traditional medicine
- Biology
- Stereochemistry
- Medicine
- Chemistry
- Cell biology
- Mitochondrion

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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