# CSF turnover dysfunction: a hidden early biomarker in iRBD?
> Grimaldi S.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105054320918
Jurnal / Konferensi: Npj Parkinson S Disease
Tahun terbit: 2026
DOI: https://doi.org/10.1038/s41531-026-01444-2
ISSN: 23738057
Kuartil SJR: Q1
Citations: 0

## Authors
- Grimaldi S.

## Abstract
Evidence in Alzheimer's disease and other dementias shows that changes in cerebrospinal fluid (CSF) turnover and perivascular spaces (PVS) volume are associated with disease progression through impairment of waste-clearance glymphatic pathways. Volume of CSF, PVS, and drainage structures such as venous sinus are mostly excluded in current MRI studies of premanifest synucleinopathy. Here, we used 7 Tesla MRI to investigate whether modifications in CSF, PVS, and venous sinus volumes occur in 18 prodromal synucleinopathy patients (namely isolated rapid-eye-movement sleep behavior disorder, iRBD) compared to 20 healthy young and 18 elderly controls. Our results demonstrated increased CSF and PVS volumes in iRBD without a matching increase in drainage venous structures, as observed in elderly controls. This suggests increased CSF and PVS fluid stasis, possibly due to impaired CSF filtration, a mechanism that could reduce glymphatic function and exacerbate the neurodegenerative process in iRBD.

## Keywords
- Medicine
- Biomarker
- Internal medicine
- Neurology
- Oncology
- Disease
- Bioinformatics
- Cancer research
- Parkinson's disease
- Cerebrospinal fluid
- MEDLINE

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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