# Emerging opportunities in network pharmacology mechanisms of Saussurea costus in regulating inflammation and intestinal barrier dysfunction in non-alcoholic fatty liver disease
> Pontjosudargo F.A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105050385955
Jurnal / Konferensi: Gaceta Medica De Caracas
Tahun terbit: 2026
DOI: https://doi.org/10.47307/GMC.2026.134.3.15
ISSN: 03674762
Kuartil SJR: Q4
Citations: 0

## Authors
- Pontjosudargo F.A.

## Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous metabolic liver disorder involving excessive lipid deposition, redox imbalance, inflammatory activation, and disruption of gut-liver axis homeostasis. Loss of epithelial junction integrity and increased intestinal permeability are increasingly considered important contributors to disease progression. Saussurea costus contains several phytochemicals with reported antioxidant and anti-inflammatory potential, but its molecular relevance to NAFLD and intestinal barrier regulation remains incompletely defined. Objective: This study aimed to predict the molecular targets and biological pathways through which Saussurea costus may influence NAFLD, with particular emphasis on inflammation and intestinal junction-associated mechanisms. Methods: Phytochemicals reported from Saussurea costus were compiled from the literature and screened for drug-likeness using ADMETlab. Chemical information, including canonical SMILES and three-dimensional structures, was obtained from PubChem. Putative compound targets and NAFLD-related targets were retrieved from public resources and integrated to identify shared targets.

## Keywords
- Inflammation
- Fatty liver
- Intestinal permeability
- Traditional medicine
- Pharmacology
- Antioxidant
- Disease
- Medicine
- Chemistry
- Biology
- Anti-inflammatory
- Lipid metabolism
- Hepatoprotection
- Liver disease
- Metabolic pathway
- Inflammatory bowel disease

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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