Prevalence of Bovine Tuberculosis in Cattle and Cattle-Derived Products in Indonesia: A Systematic Review and Meta-Analysis

Abstract

the primary cause of TB in humans (Kurniati et al., 2019).However, another important species within this complex, Mycobacterium bovis, is responsible for bovine tuberculosis (bTB), a chronic infectious disease primarily affecting cattle and other mammals.The disease has significant zoonotic potential and remains a public health concern in Research ArticleAbstract | Bovine tuberculosis (bTB), primarily caused by Mycobacterium bovis (M.bovis), is an important zoonotic disease in developing countries, including Indonesia.This study aimed to estimate the pooled prevalence of bovine tuberculosis in cattle and cattle-derived products in Indonesia and to evaluate its implications within a One Health framework.A systematic literature search was conducted in PubMed, ScienceDirect, Google Scholar, and Portal Garuda following PRISMA 2020 guidelines.Studies published between 2000 and 2025 reporting the prevalence of M. bovis or members of the Mycobacterium tuberculosis complex (MTBC) in cattle or cattle-derived products in Indonesia were included.Data were extracted on study characteristics, sample types, diagnostic methods, and prevalence estimates.Meta-analysis was performed using MetaXL 5.3 software with a random-effects model and Freeman-Tukey double arcsine transformation.A total of 9 studies met the inclusion criteria and were included in the meta-analysis.The pooled prevalence of bTB was 8.0% (95% CI: 0.0-23.0),with substantial heterogeneity (I² = 98%).Subgroup analysis showed higher prevalence in milk samples 17.0% (95% CI: 0.0-56.0)compared with non-milk samples 2.0% (95% CI: 0.0-6.0), in dairy cattle prevalence 13.0% (95% CI: 0.0-38.0)compared with beef cattle 0.2% (95% CI: 0.0-1.0)and in PCR-based methods 10.0% (95% CI: 0.0-29.0)compared with non-PCR based methods 5.0% (95% CI: 0.0-17.0).However, these findings should be interpreted cautiously due to wide confidence intervals and considerable variability across studies.In conclusion, bovine tuberculosis has been reported in cattle and cattle-derived products in Indonesia, although the overall estimate remains uncertain.Strengthening surveillance and implementing integrated One Health approaches are important to improve disease control.

Access to Document

Other files and links

• Link to publication in Scopus
• Open Access Version Available

Fingerprint