Waist circumference, blood glucose, serum myeloperoxidase, xanthine oxidase and oxidized low‑density lipoprotein as determinants of blood pressure among adults with abdominal obesity

Abstract

Obesity is a risk factor for increased blood pressure and diabetes, in which the relationship is mediated by the action of several pro-inflammatory mediators such as myeloperoxidase (MPO), xanthine oxidase (XO) and oxidized low-density lipoprotein (Ox-LDL).The present study aimed to evaluate the contribution of serum MPO, XO and Ox-LDL as determinants of blood pressure in adults with abdominal obesity.A total of 86 adults with abdominal obesity were recruited, then waist circumference (WC), fasting serum glucose (FSG), MPO, XO and serum Ox-LDL were measured.The contributions of these parameters to systolic blood pressure (SBP) and diastolic blood pressure (DBP) were then assessed.Multivariate analysis revealed that the determinant factors of SBP were WC, FSG, MPO and XO (β=0.418,0.328, 0.282 and 0.248 respectively; all P<0.05; adjusted R 2 =41.5%), while the determinants of DBP were FSG, WC and MPO (β=0.310,0.284 and 0.274, respectively; all P<0.05; adjusted R 2 =24.8%).In conclusion, MPO has a role as a determinant factor for SBP and DBP, whilst XO has a role as a determinant factor for SBP, and Ox-LDL does not have a significant role in blood pressure.

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