# The use of flavonoids in the prevention and treatment of skin aging. A systematic review of clinical potential Zastosowanie flawonoidów w profilaktyce i terapii starzenia się skóry. Przegląd systematyczny możliwości klinicznych
> Kuncoro C.S.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105047386607
Jurnal / Konferensi: Aesthetic Cosmetology and Medicine
Tahun terbit: 2026
DOI: https://doi.org/10.52336/ACM.2026.020
ISSN: 27193241
Kuartil SJR: Q3
Citations: 1

## Authors
- Kuncoro C.S.

## Abstract
Introduction: Skin aging is a natural process accompanied by a gradual deterioration of its structure and function. Flavonoids, belonging to the group of plant-derived polyphenols, exhibit antioxidant, anti-inflammatory, antiviral, and antibacterial properties. This allows them to reduce premature skin aging caused by oxidative stress and also inhibit the activity of enzymes involved in the degradation of extracellular matrix components. Aim: This systematic review aimed to critically synthesize and evaluate existing clinical evidence on the efficacy and therapeutic potential of flavonoids in the prevention and treatment of skin aging. Materials and Methods: A systematic review of the PubMed, Cochrane, ScienceDirect, and Google Scholar databases identified English-language studies from 2005 to 2025. Inclusion criteria were observational, open-label, or RCT designs in human. Meta-analysis was performed using RevMan 5.4.1. Random-effect model was used to pool standardized mean difference (SMD) for skin wrinkles and skin elasticity parameters, with 95% confidence interval (CI). The ROB2 or ROBINS-I were used to assess risk of bias in the included studies. Results: The use of flavonoids significantly improves skin elasticity and reduces the severity of wrinkles compared to the pre-therapy state. These results suggest that flavonoids may act as an effective anti-aging agent. Conclusions: Flavonoids, thanks to their strong antioxidant and anti-inflammatory properties and protective effect on collagen, play an important role in the prevention and treatment of skin aging. Their use can contribute to reducing the appearance of wrinkles and improving skin elasticity.

## Keywords
- Medicine
- Skin Aging
- Human skin
- Clinical trial
- Randomized controlled trial
- Confidence interval
- Dermatology
- Oxidative stress
- Pharmacology
- Meta-analysis
- Systematic review
- Antioxidant
- Skin thickness
- MEDLINE

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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