# Diagnostic Performance of Immature Platelet Fraction in Patients with Suspected Deep Vein Thrombosis
> Kurnia Q.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105045264328
Jurnal / Konferensi: Healthcare Switzerland
Tahun terbit: 2026
DOI: https://doi.org/10.3390/healthcare14132018
ISSN: 22279032
Kuartil SJR: Q1
Citations: 0

## Authors
- Kurnia Q.

## Abstract
Background/Objectives: Deep Vein Thrombosis (DVT) remains a major cause of morbidity and mortality. Current diagnostic approaches rely on the Wells score and D-dimer, but both have limitations. Immature Platelet Fraction (IPF) has emerged as a potential biomarker reflecting platelet activation and thrombosis activity. The aim of this study was to compare the diagnostic performance of IPF, the Wells score, and D-dimer for the diagnosis of DVT confirmed by Doppler ultrasonography. Methods: This retrospective diagnostic accuracy study included 53 patients with suspected DVT treated at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Patients underwent clinical assessment using the Wells score, laboratory examination of D-dimer and IPF, and Doppler ultrasonography as the reference standard. Associations were analyzed using Chi-square and multivariate logistic regression. Diagnostic performance was evaluated using ROC curve analysis. Results: DVT was confirmed in 32 patients (60.4%). A high Wells score was associated with DVT (OR 4.762; p = 0.009), as was elevated D-dimer (OR 6.364; p = 0.005). Elevated IPF demonstrated a significant association with DVT (OR 14.000; p < 0.001). In multivariate analysis, IPF remained significantly associated with DVT (OR 11.819; p = 0.007). ROC analysis demonstrated that IPF had the highest diagnostic accuracy among individual variables (AUC 0.832), followed by D-dimer (AUC 0.753) and Wells score (AUC 0.695). Combination analysis improved diagnostic performance (AUC 0.845). Conclusions: IPF demonstrated promising diagnostic performance in patients with suspected DVT. Nevertheless, these findings should be considered preliminary and require confirmation in larger prospective studies before clinical implementation can be considered.

## Keywords
- Medicine
- Thrombosis
- Internal medicine
- Receiver operating characteristic
- Diagnostic accuracy
- Deep vein
- Multivariate analysis
- Prospective cohort study
- Logistic regression
- Area under the curve
- Portal vein thrombosis
- Radiology
- Predictive value of tests
- Gastroenterology
- Platelet
- Diagnostic test
- Retrospective cohort study
- Mean platelet volume
- Biomarker
- Venous thrombosis
- Gold standard (test)
- Surgery
- Clinical significance
- Clinical Practice
- Physical examination
- Cardiology
- Clinical diagnosis
- Ultrasonography
- Vein

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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