# Prenatal maternal antibiotic use increases the risk of childhood eczema: a systematic review and meta-analysis
> Petrás S.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105044008676
Jurnal / Konferensi: Scientific Reports
Tahun terbit: 2026
DOI: https://doi.org/10.1038/s41598-026-51441-x
ISSN: 20452322
Kuartil SJR: Q1
Citations: 0

## Authors
- Petrás S.

## Abstract
Early-life disruption of microbiome development is known to impair health; however, the long-term effects of pregnancy-related pharmacological alterations to the maternal gut microbiota on offspring health remain unclear. This meta-analysis aimed to evaluate the impact of maternal antibiotic use (either prenatal or intrapartum) on the risk of childhood atopic dermatitis, based on cohort and case-control studies. Literature searches were conducted in EMBASE, PubMed, Cochrane, and Web of Science databases using predefined PICO (patients, intervention, comparison, outcome) criteria. Overall, our meta-analysis included 30 studies with a total of 4,125,143 mothers and 4,346,050 children. Using the random effects model, our study found that prenatal antibiotic use was associated with higher odds of atopic dermatitis in childhood (aOR: 1.32; 95% CI: 1.12; 1.56). This result remained significant after adjusting publication bias by the trim-and-fill method (aOR: 1.22; 95% CI: 1.03; 1.44), highlighting the potential relevance of antibiotic prescribing practices during pregnancy in relation to childhood atopic disease risk. Intrapartum antibiotic use was not associated with elevated risk for atopic dermatitis in the children (OR: 1.64; 95% CI: 0.84; 3.17). Prenatal antibiotic use appears to have a modest effect on atopic dermatitis in offspring.

## Keywords
- Atopic dermatitis
- Medicine
- Pregnancy
- Microbiome
- Offspring
- Antibiotics
- Odds ratio
- Prenatal care
- Cohort study
- Prenatal development
- Cohort
- Atopy
- Pediatrics
- MEDLINE
- Early childhood
- Allergy
- Disease
- Risk factor
- Obstetrics
- Odds
- Meta-analysis
- Gestation

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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