Haematology profiles in patients with essential and reactive thrombocytosis

Abstract

Background: An elevated platelet count, either primary (such as essential thrombocytosis) or secondary (such as reactive thrombocytosis), is the hallmark of thrombocytosis. These two conditions have different clinical implications and management approaches but are often difficult to distinguish clinically. Routine hematological tests, including platelet count, mean platelet volume, platelet distribution width, leukocyte count, and hemoglobin, have the potential to serve as easily accessible initial parameters to help differentiate between the two conditions. The purpose of this study is to assess how routine hematological indicators can be used to distinguish between essential thrombocytosis and reactive thrombocytosis. Materials and Methods: A retrospective cross-sectional analytical observational study was conducted at Makassar's Dr. Wahidin Sudirohusodo General Hospital between November 2024 and January 2025. The study subjects were patients with platelet counts ≥450,000/mm³. The diagnosis of essential and reactive thrombocytosis was established based on the evaluation of thrombocytosis persistence and peripheral blood smear findings, with bone marrow aspiration used solely for diagnostic confirmation as documented in medical records. Results: A total of 90 thrombocytosis patients were analyzed, including 37 patients ET and 53 patients RT. The mean age in ET was 41.1±11.1 years and in RT was 45.2±10.2 years. The mean WBC count was higher in ET than in RT (19.06±14.8 vs. 15.1±6.5 ×10³/µL; p=0.265). ET had significantly higher platelet counts (1,418.3±735.9 vs. 605±126.5 ×10³/µL; p<0.001) and Hb levels (13.06±2.3 vs. 8.7±1.8 g/dL; p<0.001). MPV values were slightly higher in ET (8.9±1.0 vs. 8.79±0.8 fL; p<0.001), while PDW did not differ significantly between the two groups (11.0±3.4 vs. 8.8±1.6 fL; p=0.311). Conclusion: Hemoglobin, MPV, and platelet count were all higher in essential thrombocytosis than in reactive thrombocytosis

Access to Document

Other files and links

• Link to publication in Scopus
• Open Access Version Available

Fingerprint