# Fecal short-chain fatty acids and growth factors (IGF-1, TGF-β1, Leptin) in stunting children
> Handayani D.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105041634842
Jurnal / Konferensi: Gaceta Medica De Caracas
Tahun terbit: 2026
DOI: https://doi.org/10.47307/GMC.2026.134.2.9
ISSN: 03674762
Kuartil SJR: Q4
Citations: 0

## Authors
- Handayani D.R.

## Abstract
Background: Stunting is not only caused by macronutrient deficiencies but also involves impaired metabolic signaling through the gut-bone axis. Short-Chain Fatty Acids (SCFAs) from the gut microbiota are strongly suspected to influence the secretion of bone growth regulators, including IGF-1, TGF-β1, and leptin. This study aims to analyze the simultaneous effects of SCFA (acetate, propionate, butyrate) on three biomarkers in children with stunting. Method: A cross-sectional study involving 50 children (25 stunting, 25 non-stunting) aged 36–60 months in West Bandung Regency. SCFA concentrations in feces were measured by gas chromatography, and ELISA analyzed serum biomarkers (IGF-1, TGF-β1, leptin). Data analysis used comparative tests, bivariate correlations, and path analysis. Results: No significant differences were found in absolute SCFA levels or serum biomarkers between the two groups.

## Keywords
- Feces
- Biology
- Food science
- Gut flora
- Volatile fatty acids
- Physiology
- Fatty acid
- Secretion
- Internal medicine
- Chemistry
- Endocrinology
- Medicine
- Disease
- Metabolism
- Nutrient

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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