# Synthesis of 3-(4-Hydroxy-3-Methoxyphenyl)-1-(2-Hydroxyphenyl)-Propenone as a Colorimetric Chemosensor for Hydrogen Phosphate Anions
> Nur A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105041194814
Jurnal / Konferensi: Jurnal Kimia Valensi
Tahun terbit: 2026
DOI: https://doi.org/10.15408/jkv.v12i1.46467
ISSN: 24606065
Kuartil SJR: Q4
Citations: 0

## Authors
- Nur A.

## Abstract
Hydrogen phosphate is an important anion in environmental and biological systems; however, its excessive presence in water can contribute to eutrophication and water quality degradation. The synthesis and application of 3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)-propenone (HMPP) as a colorimetric chemosensor for hydrogen phosphate (HPO₄²⁻) anions have been investigated. HMPP was synthesized via Claisen–Schmidt condensation of vanillin and 2-hydroxyacetophenone, obtained in 34% yield of the target compound. The colorimetric response of HMPP was evaluated toward various anions, including F⁻, Cl⁻, Br⁻, CN⁻, HPO₄²⁻, and CO₃²⁻. The results showed that HMPP exhibited a distinct response toward HPO₄²⁻; however, the presence of other anions caused varying degrees of interference, with CO₃²⁻ showing minimal effect, while Cl⁻, CN⁻, and Br⁻ reduced the response to a greater extent. This behavior is attributed to hydrogen-bonding interactions between HMPP and HPO₄²⁻, which enhance intramolecular charge transfer (ICT). The applicability of HMPP was further evaluated in spiked tap water samples, demonstrating satisfactory recovery in the range of 105.47–107.50%, indicating acceptable accuracy and reliability. Therefore, HMPP demonstrates potential as a colorimetric chemosensor for hydrogen phosphate anions in water samples.

## Keywords
- Chemistry
- Phosphate
- Colorimetry
- Inorganic chemistry
- Hydrogen
- Yield (engineering)
- Hydrogen phosphate
- Condensation
- Intramolecular force
- Tap water
- Ion
- Colorimetric analysis
- Photochemistry
- Nuclear chemistry
- Vanillin

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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