# Effectiveness of injectable platelet-rich fibrin (I-PRF) as a sole therapy in temporomandibular joint internal derangement with reduction: A systematic review
> Nursanti N.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105040562434
Jurnal / Konferensi: Cranio Journal of Craniomandibular and Sleep Practice
Tahun terbit: 2026
DOI: https://doi.org/10.1080/08869634.2026.2670638
ISSN: 08869634
Kuartil SJR: Q2
Citations: 0

## Authors
- Nursanti N.

## Abstract
OBJECTIVE: Temporomandibular joint internal derangement with reduction commonly causes pain, joint clicking, and limited jaw movement. Injectable platelet-rich fibrin (I-PRF), an autologous concentrate containing growth factors, has emerged as a potential regenerative treatment. METHODS: This systematic review assessed the effectiveness of intra-articular I-PRF as a sole therapy for temporomandibular disorders (TMD). A literature search of PubMed, Scopus, Embase, and Web of Science (2015-2025) identified five eligible studies following PRISMA guidelines. RESULTS AND DISCUSSION: Included studies reported reduced pain, improved mouth opening, and decreased joint sounds after I-PRF therapy, without significant adverse effects. However, variations in study design and treatment protocols were noted. CONCLUSION: Overall, current evidence indicates that I-PRF may improve symptoms and jaw function as a minimally invasive conservative treatment for TMD. Nonetheless, the evidence remains limited due to methodological heterogeneity and the predominance of non-randomized studies, highlighting the need for further high-quality randomized controlled trials.

## Keywords
- Medicine
- Temporomandibular joint
- Derangement
- Surgery
- Randomized controlled trial
- Adverse effect
- Dentistry
- Fibrin
- Systematic review
- Reduction (mathematics)
- Clinical trial
- Meta-analysis
- Orthodontics
- MEDLINE
- Conventional treatment
- Conservative treatment

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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