# Deceleration of Proton Exchange between Monosaccharides and Water by Metallocryptand and Related Compounds
> Firdausiah S.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105039960813
Jurnal / Konferensi: Inorganic Chemistry
Tahun terbit: 2026
DOI: https://doi.org/10.1021/acs.inorgchem.6c00780
ISSN: 00201669
Kuartil SJR: Q1
Citations: 0

## Authors
- Firdausiah S.

## Abstract
We report an unexpected yet powerful ability of a tris(salen) nickel(II) metallocryptand LNi 3 to dramatically decelerate proton exchange between monosaccharides and water. In the presence of only 0.025 equiv of LNi 3, the exchange rates of glucose hydroxy protons with water decreased by up to 74-fold. Similar deceleration effects were also observed for mannose, fructose, galactose, and methanol. Comparative studies using a mononuclear analogue ( L m Ni ) and a metal-free analogue ( H 6 L ) suggest that the salen framework itself reorganizes the local hydrogen-bonding network. These findings identify salen-based molecules as a new class of proton exchange modulators under nonphysiological conditions and provide a conceptual basis for new opportunities to study hydration and for molecular-level control of dynamic processes in glycobiology.

## Keywords
- Chemistry
- Monosaccharide
- Proton
- Molecule
- Inorganic chemistry
- Hydrogen bond
- Computational chemistry
- Hydrogen
- Physical chemistry
- Chromatography

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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