# Diagnostic value of diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) and dynamic contrast-enhanced (DCE) MRI 3-Tesla on histopathologic features of meningioma
> Farras M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105039823581
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2026
DOI: https://doi.org/10.23736/S0393-3660.24.05864-9
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Farras M.

## Abstract
BACKGROUND: Meningiomas, primarily benign central nervous system tumors, have an incidence rate rising to 10.82 per 100,000 globally. Histologically confirmed meningiomas constitute 37.6% of primary central nervous system (CNS) tumors, with recurrence rates reaching 20% over 10 years. Utilizing diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) and dynamic contrast-enhanced (DCE) Magnetic resonance imaging (MRI) has proven valuable for assessing meningioma grade, distinguishing tumor types, and guiding treatment. This study aims to evaluate the diagnostic efficacy of DWI-ADC and DCE MRI in histopathological grading of meningiomas in Makassar.METHODS: This observational analytic study, with a cross-sectional approach, was conducted from June to September 2024, using retrospective data from January 2021 to March 2024 on meningioma patients who underwent contrast-enhanced head MRI. Diagnoses were histopathologically confirmed. SPSS version 25.0 for Windows was used for all analyses, with univariate analysis describing variables. Bivariate analysis, including Mann-Whitney and χ2 tests, compared DWI-ADC and DCE MRI parameter values, with a significance level of P<0.05.RESULTS: A total of 50 samples were included in this study. ADC value analysis for distinguishing benign from atypical/malignant meningiomas showed 96% accuracy, with 95.3% sensitivity and 100% specificity. Max slope analysis achieved 76% accuracy, with 76.7% sensitivity and 71.4% specificity. DWI-ADC parameters had higher diagnostic accuracy than DCE in differentiating between benign and atypical/malignant meningiomas.CONCLUSIONS: ADC value and Max slope effectively differentiate benign from atypical/malignant meningiomas, with DWI-ADC parameters showing greater diagnostic accuracy than DCE for this distinction.

## Keywords
- Meningioma
- Medicine
- Grading (engineering)
- Magnetic resonance imaging
- Diffusion MRI
- Univariate analysis
- Effective diffusion coefficient
- Radiology
- Nuclear medicine
- Medical diagnosis
- Univariate
- Bivariate analysis
- Diffusion-Weighted Magnetic Resonance Imaging
- Retrospective cohort study
- Statistical significance
- Diagnostic accuracy
- Statistical analysis
- Imaging phantom

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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