# Comparison of the homeostasis model assessment of insulin resistance (HOMA-IR) and the triglyceride-glucose index (TyG index) in non-diabetic young adults with obesity
> Awaluddin R.B.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105039788574
Jurnal / Konferensi: Romanian Medical Journal
Tahun terbit: 2026
DOI: https://doi.org/10.37897/RMJ.2026.1.8
ISSN: 12205478
Kuartil SJR: Q4
Citations: 0

## Authors
- Awaluddin R.B.

## Abstract
Background and objectives. Obesity is characterized by excessive fat accumulation resulting from an imbalance between energy intake and expenditure and is strongly associated with insulin resistance (IR). This study aimed to evaluate the suitability of the homeostasis model assessment of insulin resistance (HOMA-IR) and the triglyceride–glucose index (TyG index) in identifying IR across different obesity measurement indices in non-diabetic young adults. Materials and methods. This cross-sectional study included 100 general practitioners aged 20–39 years in Makassar, Indonesia, from January to March 2023. Obesity was assessed using body mass index (BMI), waist circumference (WC), and body fat percentage (BF%). Insulin resistance was estimated using HOMA-IR and the TyG index. Concordance between obesity indices and IR markers was analyzed using Spearman’s correlation test. Results. A total of 98 subjects were included in the analysis (mean age 31 years). The prevalence of obesity was 57.2% based on BMI, 77.6% based on WC, and 92.9% based on BF%. The HOMA-IR cut-off value was 2.03, while the TyG index cut-off was 4.33. Strong positive correlations were observed between BMI and HOMA-IR (r = 0.667, p < 0.001) and between WC and HOMA-IR (r = 0.641, p < 0.001). Moderate correlations were found between BMI and the TyG index (r = 0.456, p < 0.001) and between WC and the TyG index (r = 0.455, p < 0.001). A weak correlation was observed between BF% and HOMA-IR (r = 0.304, p = 0.002), while no significant correlation was found between BF% and the TyG index (r = 0.033, p = 0.745). Conclusion. BMI and WC showed stronger correlations with both HOMA-IR and the TyG index compared to BF% in young non-diabetic adults. These findings suggest that simple anthropometric measures, particularly BMI and WC, remain practical and reliable indicators for identifying insulin resistance in this population.

## Keywords
- Medicine
- Waist
- Obesity
- Insulin resistance
- Body mass index
- Internal medicine
- Concordance
- Endocrinology
- Correlation
- Index (typography)
- Homeostatic model assessment
- Young adult
- Energy homeostasis
- Mass index
- Body adiposity index
- Concordance correlation coefficient
- Body fat percentage
- Anthropometry
- Insulin
- Energy expenditure
- Body volume index
- Homeostasis
- Continuous variable

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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