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Correlation of DWI-ADC and Bone-RADS on histopathology subtypes of osteosarcoma
Aisyah R.N.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Osteosarcoma is the most common primary bone malignancy in children and adolescents, often affecting the metaphyseal regions of long bones. Magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) analysis, plays a crucial role in tumor evaluation. The Bone Reporting and Data System (Bone-RADS) aids risk stratification. The aim of this study was to analyze the correlation between DWI-ADC values, Bone-RADS classifications, and histopathological subtypes of osteosarcoma.METHODS: This analytic observational study used a cross-sectional design, analyzing secondary data from the Picture Archiving and Communication System (PACS) and patient medical records. The study included patients diagnosed with osteosarcoma who underwent conventional radiography and musculoskeletal MRI with DWI-ADC sequences, confirmed by histopathological analysis. Statistical analysis was conducted using the Spearman test, with significance set at P<0.05.RESULTS: The study included 54 subjects, predominantly male (79.6%), with a mean age of 19.61 years. Conventional osteosarcoma was the most common subtype (33%), while parosteal and periosteal osteosarcomas were the least frequent (1.9%). The femur was the most commonly affected site (51.9%). There was no significant correlation between DWI-ADC and osteosarcoma histopathological subtypes (P=0.449). However, ADC values exhibited a moderate negative correlation with histopathological subtypes (P<0.001). No significant correlation was found between radiographic Bone-RADS scores and osteosarcoma subtypes (P=0.572).CONCLUSIONS: Conventional osteosarcoma was the most prevalent subtype, with the femur being the most common tumor site. While no correlation was observed between DWI-ADC and histopathological subtypes, ADC values demonstrated a moderate negative correlation with osteosarcoma subtypes. No significant relationship was found between Bone-RADS scores and histopathology. These findings highlight the need for further research to refine imaging-based diagnostic tools for osteosarcoma assessment.