# Comparison of the effectiveness of gelatin spray and Aquadest in acute wound healing in Wistar rats
> Fajriana A.P.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105037878202
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2026
DOI: https://doi.org/10.23736/S0393-3660.25.05955-8
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Fajriana A.P.

## Abstract
BACKGROUND: The skin is a protective barrier for the body but can be susceptible to damage, resulting in wounds that compromise tissue continuity. The healing process involves three key stages: inflammation, regeneration, and strengthening, facilitated by cytokines such as vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6). Effective wound care is essential, with options like Aquadest and gelatin demonstrating positive outcomes. Gelatin, a biocompatible material, promotes healing by elevating levels of growth factors. The aim of this study was to compare the efficacy of gelatin spray and Aquadest in wound healing in Wistar rats.METHODS: This experimental study involved 27 male Wistar rats divided into nine groups to compare the effects of gelatin spray and Aquadest on wound healing. Wound diameter, and levels of IL-6 and VEGF were assessed on days 2, 7, and 14 using macroscopic and Enzyme-Linked Immunosorbent Assay (ELISA) methods.RESULTS: Statistical analysis showed that the Gelatin group improved early wound healing by significantly reducing wound diameter and VEGF levels, particularly from Day 7 to 14, though intergroup differences were not statistically significant. IL-6 changes were significant only in the Aquadest group.CONCLUSIONS: This study found that gelatin treatment significantly reduced wound diameter and decreased VEGF levels early, but only Aquadest treatment showed significant differences in IL-6 levels, highlighting the need for further research with larger samples and longer follow-up.

## Keywords
- Gelatin
- Wound healing
- Medicine
- Biomedical engineering
- Surgery
- Wound care
- Biocompatible material
- Significant difference
- VEGF receptors
- Materials science
- Statistical analysis
- Gelatin sponge
- Rat model

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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