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Creatinine levels and its correlation with bleeding volume in acute hemorrhagic stroke
Surianto D.F.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Hemorrhagic stroke (HS) is global concern due to its association with high morbidity and mortality. Creatinine is a product of muscle metabolism, and commonly used as a biomarker for renal function. However, limited studies have investigated the creatinine levels and its correlation with larger bleeding volumes. The purpose of this study was to determine whether creatinine levels are correlated with larger bleeding volume in HS patients, and may provide valuable insight to support early diagnosis and management during acute phase.METHODS: This retrospective cross-sectional study included 134 acute HS patients admitted to Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia, from January 2023 to January 2025. Data on demographics, creatinine levels (Cr), and bleeding volume were collected. Spearman’s correlation analysis was used to examine the relationship between creatinine levels and bleeding volume.RESULTS: Among the 134 subjects, 53.7% with normal creatinine levels had bleeding volume less than 30 cc. while a higher proportion (18.7%) of subjects with impaired creatinine levels had bleeding volume ≥30 cc. A χ2 analysis revealed a statistically significant correlation (P<0.001). Additionally, a significant positive correlation was found between creatinine levels and bleeding volume r=0.211, P=0.015 (P<0.05), indicating that higher creatinine levels are associated with larger volumes in HS patients.CONCLUSIONS: Elevated creatinine level are associated with larger bleeding volume in patients with HS. This finding suggest that creatinine levels may serve as an indicator for predicting hemorrhagic volume.