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Effectiveness of topical microbiome containing Lactobacillus plantarum on Staphylococcus aureus colonization in atopic dermatitis patients: a randomized clinical trial
Nuhurridha W.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Atopic dermatitis (AD) is a chronic skin condition characterized by pruritus, lichenification, and impaired skin barrier function, often linked to an imbalance in the skin microbiome. Previous studies, including a 2017 randomized controlled trial, demonstrated that prebiotics containing Lactobacillus plantarum IS-10506 effectively reduced Scoring Atopic Dermatitis (SCORAD) scores in AD patients, although serum IgE levels remained unchanged. However, research on the use of topical microbiomes for AD management is still limited. This study aims to assess the effectiveness of topical microbiomes containing L. plantarum in reducing Staphylococcus aureus colonization.METHODS: A randomized control trial that involved 23 AD patients, assessing SCORAD scores and skin swabs. The treatment group used L. plantarum cream, while the control group used Vaseline. Follow-up evaluations were performed after 4 weeks. S. aereus colonization numbers were measured by microbial culture, and statistical tests, including the Kolmogorov-Smirnov Normality Test, T-test, and Wilcoxon Test, were used with a significance threshold of P<0.05.RESULTS: The study of 23 participants showed significant reductions in S. aureus colonization in the treatment group, from 17.39% to 0%, and improvements in SCORAD scores.CONCLUSIONS: Topical microbiomes containing L. plantarum significantly reduced SCORAD scores and S. aureus colonization in AD patients.