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Investigating serum chemerin levels and adipose insulin resistance in non-diabetic adults with and without central obesity: a cross-sectional study
Lumula F.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Obesity is a global health problem with increasing prevalence. Adipose tissue enlargement in obesity leads to adipokine dysregulation, including elevated chemerin levels, which are involved in fat tissue formation, angiogenesis, and inflammation. Adipokine dysregulation contributes to insulin resistance (IR), increasing lipolysis and free fatty acids (FFA), measurable through adipose tissue insulin resistance (Adipo-IR). This study analyzed serum chemerin levels and Adipo-IR in non-diabetic adults with and without central obesity.METHODS: A cross-sectional study was conducted with 60 non-diabetic adults, divided into two groups: 30 with central obesity and 30 without. Serum chemerin levels and Adipo-IR were measured using enzyme-linked immunosorbent assay (ELISA) methods and analyzed statistically to compare the groups and assess correlations.RESULTS: Mean serum chemerin levels were higher in individuals with central obesity (9.04±2.00 ng/mL) compared to those without (7.99±2.29 ng/mL), though the difference was not statistically significant (P=0.062). Mean Adipo-IR values were also higher in the central obesity group (4.49±5.88) than in the non-obese group (2.97±4.97), with no significant difference (P=0.080). A significant positive correlation was observed between serum chemerin levels and Adipo-IR in the central obesity group (r=0.486; P=0.006).CONCLUSIONS: Serum chemerin levels and Adipo-IR are elevated in individuals with central obesity compared to those without. While the differences were not statistically significant, a notable correlation between serum chemerin and Adipo-IR was identified in the central obesity group, suggesting chemerin’s role in metabolic dysregulation in obesity.