# Regulation of IL-10 by Herbal and Hormonal Therapy: The Impact of Eleutherine Bulbosa and Tamoxifen in an Experimental Breast Cancer Model
> Rahmi

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105034699810
Jurnal / Konferensi: Archives of Breast Cancer
Tahun terbit: 2026
DOI: https://doi.org/10.32768/ABC.4029185736-402
ISSN: 23830433
Kuartil SJR: Q2
Citations: 0

## Authors
- Rahmi

## Abstract
Background: Male breast cancer, though rare, requires reliable diagnostic and prognostic markers. This study evaluated tumor markers, hormonal receptors, and inflammatory biomarkers in male breast cancer. Methods: A case–control study included 150 men with breast cancer and 50 matched controls (38–52 years). Diagnosis was confirmed by clinical evaluation, mammography, and histopathology. Serum was collected and stored at −80°C. Tumor markers—cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) and inflammatory biomarkers, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) were measured using enzyme-linked immunosorbent assay (ELISA). Hormonal receptors, estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR) were measured by Cobas e411 immunoassay. Results: Age and education were similar between groups. Patients had higher smoking rates (45% vs. 20%, p = 0.01) and body mass index (28.6 ± 3.2 vs. 26.1 ± 2.8 kg/m², p = 0.02). Tumor markers, hormonal receptors, and inflammatory biomarkers were significantly elevated in patients (p < 0.001). Strong correlations were found between CA15-3 and IL-6 (r = 0.68), ER and CRP (r = 0.55), and PR and TNF-α (r = 0.61). Conclusions: Elevated tumor markers, hormonal receptors, and inflammatory biomarkers indicate a link between inflammation, hormonal regulation, and tumor progression, highlighting their diagnostic and prognostic value in male breast cancer.

## Keywords
- Medicine
- Breast cancer
- Hormone
- Carcinoembryonic antigen
- Internal medicine
- Oncology
- Estrogen receptor
- Hormonal therapy
- Estrogen
- Hormone receptor
- Cancer
- CA15-3
- Biomarker
- Tumor necrosis factor alpha
- Receptor
- Androgen
- Progesterone receptor
- Body mass index
- Androgen receptor
- Tumor marker
- Antigen
- Breast tumor
- Inflammatory breast cancer
- Endocrinology
- Prostate-specific antigen
- Cancer biomarkers
- Mammary gland
- Tumor M2-PK
- Cancer antigen

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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