# Analysis of clinical features and cytokeratin-17 expression in chronic suppurative otitis media patients with cholesteatoma in children and adult patients
> Triosah H.M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105033701395
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2026
DOI: https://doi.org/10.23736/S0393-3660.24.05845-5
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Triosah H.M.

## Abstract
BACKGROUND: Chronic suppurative otitis media (CSOM) with cholesteatoma is a severe condition causing bone erosion and potentially fatal complications. Cholesteatoma can impact adjacent bones, with different clinical presentations in adults and children. Cytokeratin-17 (CK-17), typically expressed in basal cells of complex epithelium, has been identified in cholesteatoma epithelium. The aim of this study was to investigate the clinical features and expression of CK-17 in acquired nonrecurrent cholesteatoma and correlate them with its bone destructive capacity.METHODS: This cross-sectional study, conducted in tertiary teaching hospital from April 2022 to April 2024. Cholesteatoma patients were divided into two groups: children, adults, and compared (invasive and non-invasive), according to a grading score for bone resorption based upon clinical, radiologic and intraoperative findings. Histopathological and immunohistochemical analysis of CK-17 in cholesteatoma samples was carried out using fresh acquired cholesteatoma tissues, collected during cholesteatoma surgery. Data were analyzed using SPSS version 29.0, with significance set at P<0.05.RESULTS: A total of 65 patients with COSM cholesteatoma, including 48 adults and 17 children. Adults showed more invasive characteristics (62.5%) than children (29.4%) (P=0.019). Significant clinical differences were observed in the ossicles, tegmen, and sigmoid sinus between the two groups (P<0.05). CK-17 expression patterns were not significantly different between adults and children across various layers of the epithelium (P=0.464).CONCLUSIONS: Cholesteatoma in adults is more invasive than in children, but CK-17 expression does not differ significantly between age groups.

## Keywords
- Cholesteatoma
- Medicine
- Basal (medicine)
- Middle ear
- Grading (engineering)
- Immunohistochemistry
- Chronic Suppurative Otitis Media
- Pathology
- Bone erosion
- Temporal bone
- Sinus (botany)
- Clinical significance
- Internal medicine
- Young adult
- Bone resorption
- Epithelium
- Incidence (geometry)
- Dehiscence
- Otitis

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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