# Atypical cortical neural activity in internet gaming disorder comorbid with autism spectrum disorder during a cue reactivity task: A magnetoencephalography study
> Parawansa F.B.P.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105032858117
Jurnal / Konferensi: Psychiatry and Clinical Neurosciences Reports
Tahun terbit: 2026
DOI: https://doi.org/10.1002/pcn5.70312
ISSN: 27692558
Kuartil SJR: Q3
Citations: 0

## Authors
- Parawansa F.B.P.

## Abstract
Abstract Aim Significant, positive correlations between internet gaming disorder (IGD) and autism spectrum disorder (ASD) are known. Individuals with ASD are prone to problematic internet use due to addiction or restricted interests. Here, we examined cortical neural activity in individuals with IGD comorbid with ASD during a gaming‐related cue reactivity task, using magnetoencephalography (MEG). Methods MEG was used to record neural activity in right‐handed male participants aged 11–20 years (11 IGD–ASD, 13 healthy controls; intelligence quotient [IQ] ≥ 80). IGD and ASD were diagnosed per DSM‐5‐TR criteria. During MEG recording, participants viewed gaming cues and neutral base stimuli in a cue reactivity task. Source‐level cortical activity was estimated using minimum norm estimation (MNE), and statistical comparisons were performed using two‐tailed nonparametric permutation tests with false discovery rate (FDR) correction. Results In the IGD–ASD group, neural activity was significantly elevated at 137 ms in the right fusiform gyrus during gaming cues compared with the base condition ( p = 0.000039). Between‐group comparisons under cue conditions (200–270 ms) showed higher right frontal activation ( p = 0.0028) and lower activation in left lateral occipital ( p = 0.000092), fusiform ( p = 0.00025), lingual ( p = 0.0017), and parahippocampal regions ( p = 0.000049) in the IGD–ASD group compared with controls. Conclusion The IGD–ASD group showed increased right frontal activity and decreased left occipital, fusiform, lingual, and parahippocampal activity during exposure to the gaming cue, suggesting atypical visual and cognitive processing mechanisms in this comorbid group. Further studies comparing individuals with ASD and those with IGD–ASD, as well as by examining the neurophysiological characteristics of individuals with ASD who develop or recover from IGD, might clarify the pathology of these populations.

## Keywords
- Magnetoencephalography
- Autism spectrum disorder
- Psychology
- Neural correlates of consciousness
- Cue reactivity
- Neuroscience
- Brain activity and meditation
- Autism
- Cognition
- Audiology
- Parahippocampal gyrus
- Reactivity (psychology)
- Internet addiction disorder
- Connectome
- Statistical parametric mapping
- Functional magnetic resonance imaging
- Addiction
- Posterior cingulate
- Synesthesia
- Middle frontal gyrus
- Fusiform gyrus
- Ventrolateral prefrontal cortex
- DSM-5
- Neuroimaging
- Developmental psychology
- Lingual gyrus
- Brain mapping
- Resting state fMRI
- Neural activity
- Neurodevelopmental disorder

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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