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Relationship between nasopharyngeal cancer stage with interleukin-6 and interleukin-8
Tandigala C.S.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Nasopharyngeal cancer (NPC) is a squamous cell cancer that originates from the epithelium of the nasopharyngeal mucosa and has a strong tendency to metastasize to regional lymph nodes and/or distant organs, as evidenced by histopathological examination. Interleukin-6 (IL-6) is a cytokine involved in proliferation and differentiation of malignant tumor cells, while Interleukin-8 (IL-8) is a cytokine involved in inflammation, tumorigenesis, angiogenesis, microvessels in tumors, invasion, and metastasis. This study aims to investigate the relationship of nasopharyngeal cancer stage with IL-6 and IL-8 levels.METHODS: This study is an analytic observational using a cross sectional study design that conducted from August 2023 to February 2024. Population of the study were all newly diagnosed NPC patient that treated in our center. We divided NPC patient into two groups; including early stage (stage I and II) and advanced stage (stage III-IV). Then the samples were examined using the ELISA Kit. All statistical analysis were analyzed with SPSS v25 and P value of <0.05 was considered significant.RESULTS: A total of 44 samples were collected in this study. We found that both serum IL-6 and serum IL-8 levels in blood and tissue were statistically significant higher in advanced stage NPC than early stage with both P values <0.001.CONCLUSIONS: There is a relationship between NPC stage and serum IL-6 and IL-8.